Most probably already know this, but it really helped me.......
Find an intermediate target when lining up for a shot. I've always had a tough time lining up at my target and just feeling uncomfortable with my setup.....especially when you have those tee boxes that don't line you up down the fairway. I heard a tip once that helped immensely. Stand behind the ball and look at your target. Find a discolored piece of grass or a leaf or something that is a foot or so in front of the ball that lines up at your target, too. When you address the ball, line up with that intermediate target instead of looking at the green or down the fairway. Many people use this for putting, too, but I don't.