I read somewhere that Harrington had this done, taking pains to make a hybrid just like an iron, but with the clubhead. It enables you to swing like an iron, but utilize the lower COG and mass of the larger head.
I have a stock nike slingshot, and a major tendency to hook my 20 degree hybrid. Problem was I just threw it in the bag and found it easy to hit. After the honeymoon, I realized it was going too frequently left, unless I really paid attention to it. It has a 40" graphite rather than my steel irons, and the clubhead is heavier than my fairway wood. This one lone club really has its' own rhythm, and I don't find myself needing a 205 club very often, so I don't hit it and when I do it feels off.
Those who carry two or three hybrids have a better chance to find their swing with them. I think if you just carry one, making it like an iron is the most sensible approach. I prefer the accuracy of my 3-iron at present, so it is out for me.